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SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN

sainsmedika
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Published by Universitas Islam Sultan Agung

ISSN : 20851545 EISSN : 2339093X DOI : -

Core Subject : Health,

Health Professions Medicine & Pharmacology

Sains Medika is journal of medicine and health, is a peer-reviewed and open access journal that focuses on promoting medical sciences generated from Biomedical Sciences, Public Health, Clinical Sciences, and Medical Education to integrate researches in all aspects of human health. This journal publishes original articles, reviews article, and also interesting case reports.

Arjuna Subject : -

Articles 7 Documents

Search results for , issue "Vol 12, No 1 (2021): January - June 2021" : 7 Documents clear

The Antifungal Effect of Kesum Leaf (Polygonum minus Huds) in Ethanol Extract on Microsporum gypseum Liauw, Josephine Johan; Rizki, Syarifah Nurulyanti; Natalia, Diana; Mahyarudin, Mahyarudin
Sains Medika : Jurnal Kedokteran dan Kesehatan Vol 12, No 1 (2021): January - June 2021
Publisher : Fakultas Kedokteran; Universitas Islam Sultan Agung (UNISSULA)

Introduction: Dermatophytosis or tinea is a disease found in the keratinized tissues caused by dermatophytes. The prolonged use of antifungal drugs has adverse effects on humans. Kesum leaves (Polygonum minus Huds) contains the secondary metabolite properties which can act as anti-fungi. Objective: This study aimed to determine the antifungal activity of ethanol extract of kesum leaves in inhibiting the Microsporum gypseum.Methods: Phytochemical analysis was performed using a test tube method and thin layer chromatography. The antifungal activity test used a disc diffusion method with the extract concentrations of 5%, 10%, 20%, 40%, and 80%. Kesum leaves macerated using ethanol 96% solvent. Itraconazole 8µl/disk and DMSO4 were respectively used as positive and negative control. Results: Phytochemical analysis on the ethanol extract of kesum leaves showed the secondary metabolite groups of flavonoids, alkaloids, terpenoids, phenolics, and saponins. Ethanol extract of kesum leaves did not form an inhibitory zone on the growth of Microsporum gypseum. Meanwhile in the positive control, in the form of itraconazole 8 µl/disk, the inhibition zone was formed around the disc with a mean value of 37.5 mm.Conclusion: Ethanol extract of kesum leaves (Polygonum minus Huds) has no antifungal activity against the growth of Microsporum gypseum.

The Effect of Reading Activity on Verbal Fluency in Older Adults Herawati, Fitriana; Wiyono, Nanang; Munawaroh, Siti; Hastami, Yunia
Sains Medika : Jurnal Kedokteran dan Kesehatan Vol 12, No 1 (2021): January - June 2021
Publisher : Fakultas Kedokteran; Universitas Islam Sultan Agung (UNISSULA)

Introduction: The high prevalence of dementia affecting verbal fluency have been one of the global major concerns. Therefore, strategies to maintain or improve the verbal fluency in older adults is needed. Neuroplasticity-based program in the form of reading has been shown to affect the verbal fluency. Objective: This study aims to evaluate the effect of reading activity on verbal fluency in the older adults.Methods: This was a quasi-experimental study with pretest-posttest control group design. Thirty older adults were included. The inclusion criteria were more than 60 years of age, being to speak, being able to read, scores > 24, for the Mini-Mental State Examination (MMSE) score, having intention to fill out the reading habits questionnaire criteria. The exclusion criteria were the history of hypertension, diabetes mellitus, and psychiatric disorders, head trauma injury of neurological disorders, hearing loss and alcohol use. The patients were assigned into three groups: the control group (C-G), the 15-minute reading intervention group (G-15), and 30-minute reading intervention group (G-30). The reading aloud activity was given for 14 days. The verbal fluency was evaluated. Statistical analysis was performed using oneway ANOVA, Post Hoc, and paired T-test.Results: There were significant differences among groups in post-test phonemic score (p<0.05). post-test phonemic score in G-15 and G-30 increased significantly compared to that of pre-test phonemic score (p<0.05). Meanwhile, there were no significant difference in semantic score in all groups (p>0.05).Conclusion: The reading activity intervention for two weeks affects verbal fluency in older adults by increasing the phonemic score but not semantic score.

Propolis Extracted Using CMCE Decreases TNF–α and C-Reactive Protein level of CCl4- Induced Liver Damage in Rats Saputro, Arief Adi; Nasihun, Taufiqurrachman; Hussaana, Atina
Sains Medika : Jurnal Kedokteran dan Kesehatan Vol 12, No 1 (2021): January - June 2021
Publisher : Fakultas Kedokteran; Universitas Islam Sultan Agung (UNISSULA)

Introduction: Carbon tetrachloride (CCl4) is a hepatotoxic substance inducing inflammation in liver cells. Inflammation is marked by increase in proinflammatory cytokines level such as tumor necrosis factor alpha (TNF-α), and C-reactive protein (CRP) produced by hepatocytes. Propolis extracted using continuous multi-stage countercurrent Extraction (CMCE propolis extract) contains active balsamic, caffeic acid phenetyl ester (CAPE), and flavonoids capable of affecting pro-inflammatory cytokines. Objective: to investigate the effect of CMCE propolis extract on TNF-α and CRP levels in CCl4-induced liver damage.Methods: In this study using a post test only control group design, 28 male Wistar rats were divided into four groups. The control group (C-G) was given CCl4 0.4 ml/200 g on day 14. The P3-G, P7-G, P14-G groups were treated with 3.6 mg/200 g, 7.2 mg/200 g, 14.4 mg/200 g CMCE propolis extract for 14 days and given CCl4 0.4 ml/g on day 14. The TNF-α and CRP levels were assessed using the ELISA kit one-way ANOVA and Post Hoc test (LSD) were applied for the statistical analysis. Results: TNF-α level in P14-G group (3.26 ± 0.93), P7-G (6.17+0.78), and P3-G (10.4±1.34) were significantly lower than that of C-G (17.29+1.56) (p<0.05). CRP levels in P14-G group (0.61±0.09), P7-G (1.38+0.48), and P3-G (12.01±0.65) were significantly lower than those of C-G (2.95+0.668) (p<0.05). The greatest reduction in TNF-α & CRP level was found in the group given propolis at a dose of 14.4 mg/200 g.Conclusion: The administration of CMCE propolis extract reduces TNF-α & CRP levels in CCl4-induced liver damage.

Case Reports of Left Atrial Myxoma in Elderly and Children Laksono, Sidhi; Surya, Steven Philip; Manuputty, Ferel; Lasanudin, Hengkie Frankie; Prawara, Ananta Siddhi
Sains Medika : Jurnal Kedokteran dan Kesehatan Vol 12, No 1 (2021): January - June 2021
Publisher : Fakultas Kedokteran; Universitas Islam Sultan Agung (UNISSULA)

Introduction: Cardiac myxoma is a rare heart disease. Cardiac myxoma can manifest in both intracardiac and extracardiac. This report describes the importance of a careful history taking, physical examination, echocardiography, and complete surgical resection for the management of atrial myxoma in two patients.Case Reports: We reported two cases: a 64 years old female and a 16 years old male with neurological deficit as the chief complaint. The two patients underwent brain imaging and echocardiography evaluation. Both were diagnosed with left atrial myxoma and brain infarction. Surgical resection of the left atrial myxoma was successfully done in both patients and afterward, both were being monitored in the outpatient clinic. During follow up, a gradual clinical improvement can be seen in the right extremities. Echocardiography examination was conducted at 1 month, 3 months, and 6 months follow-ups for both patients and no abnormalities were found. Discussion: Atrial myxomas are the most common primary cardiac tumors. Systemic embolization in atrial myxoma is uncommon manifest as neurological deficit with reported incidence around 20-35%. On the other hand, in stroke or transient ischemic attack patients, atrial myxoma were found in 1 out of 250 young adults and 1 out of 750 older patients. Transthoracic echocardiography (TTE) has up to 95% sensitivity on diagnosing atrial myxoma. The long-term prognosis of the patients when diagnosed and managed correctly is very good and surgery is curative with recurrence rate 1-3%. The patients in our case reports showed gradual clinical improvement with no sign of myxoma recurrence during follow up.Conclusion: Stroke is one of the extracardiac manifestations of atrial myxoma. Thus, it is crucial to evaluate the presence of atrial myxoma in stroke patients. The use of TTE is important in diagnosing atrial myxoma. Resection of atrial myxomas is curative with excellent long-term prognosis and low chance of recurrences.

THE EFFECT OF GREEN TEA AND STEVIA EXTRACT ON LIVER HISTOPATHOLOGY WISTAR RATs TYPE II DIABETES MELLITUS Novit, Elmawati; Sadhana, Udadi; Mahati, Endang
Sains Medika : Jurnal Kedokteran dan Kesehatan Vol 12, No 1 (2021): January - June 2021
Publisher : Fakultas Kedokteran; Universitas Islam Sultan Agung (UNISSULA)

Introduction: Glucose metabolism abnormality on type 2 diabetes mellitus (T2DM) caused liver damage due to dyslipidemia and increasing oxidative stress. Antidiabetic and antioxidants within green tea leaf and stevia leaf extract prevent liver damage due to T2DM complications. Objective: To investigate green tea and stevia leaf extract effects on liver histopathology on T2DM rats.Methods: This study used Post Test Only Control Group Design. A total of 30 Wistar rats were divided into 5 groups: control group (C-G), normal rats; negative control group (NC-G), T2DM induction; positive control group (PC-G), treated by Metformin; the first treatment group (T1-G), was treated by green tea leaf extract and stevia leaf extract; and the second treatment group (T2-G) was treated by a Metformin also green tea and stevia leaf extract. The treatment was given to subjects for 21 days starting 3 days after the induction of Nicotinamide (NA) and Streptozotocine (STZ). Histopathological assessment of liver cells uses assessment parameters in the form of features of necrosis, vacuolization, sinusoidal dilation and number of inflammatory cells. Hypothesis will be tested by Kruskal-Wallis (p<0,05) dan Mann-Whitney test (P<0,05) Results: The difference of liver damage in all group shows a significant difference, p<0.05. Significant differences in liver damage scores between the 2 groups there are between the negative control group and the control group (0.031), positive control (0.042), and second treatment group (0.011), and between first treatment group and second treatment group (0.041).Conclusion: The administration of green tea extract, stevia leaf, and standard drug may reduce liver damage score of Wistar with T2DM

The Effect of Coffee on Spermatozoa Motility and Morphology of BALB/c Mice Exposed to Electric Mosquito Repellent Mulyono, Yehezkiel Andrew; Prihasna, Septika Nuri; Wibowo, Dhega Anindita; Johan, Andrew; Ngestiningsih, Dwi; Juniarto, Achmad Zulfa
Sains Medika : Jurnal Kedokteran dan Kesehatan Vol 12, No 1 (2021): January - June 2021
Publisher : Fakultas Kedokteran; Universitas Islam Sultan Agung (UNISSULA)

Introduction: Electric mosquito repellent which contains d-allethrin producing free radicals, affects the quality of sperm motility and morphology. Antioxidants contained in coffee can counteract the free radicals in the body. Objective: To evaluate the effect of coffee on sperm motility and morphology of BALB/c mice exposed to electric mosquito repellent. Methods: In this experimental study was conducted with post-test only control group design, 24 BALB/c mice randomized into 4 groups. The negative control group was a group without treatment. The positive control group was exposed to electric mosquito repellent. Group P1 and P2 were exposed to electric mosquito and given the coffee solutions with the doses respectively 52 mg/0.5 mL and 78 mg/0.5 mL. The treatment was given for 35 days. On the 36th day, all mice were terminated and their sperm motility and morphology were examined. The data were then analyzed with the non-parametric test of Kruskal-Wallis. Differences were considered significant when the value of p<0.05 with confidence interval 95%.Results: The result of pairwise comparison test progressive sperm motility shows that there was a significant difference between positive control group with P2 group (p=0.006), positive control group with negative control group (p<0.001), and P1 group with negative control group (p=0.004). The result of Kruskal-Wallis test for sperm morphology shows that there was no significant difference between those four groups (p=0.885).Conclusion: Coffee can significantly increase the sperm motility but didn’t significantly increase the normal sperm morphology percentage of BALB/c mice exposed by electric mosquito repellent.

The Effect of Moderate-Intensity Physical Exercise on Interleukin-6 Level and Lymphocyte Count in Leprosy Reaction Patient Roy, Adryan; Nasihun, Taufiqurrachman; Sumarawati, Titiek
Sains Medika : Jurnal Kedokteran dan Kesehatan Vol 12, No 1 (2021): January - June 2021
Publisher : Fakultas Kedokteran; Universitas Islam Sultan Agung (UNISSULA)

Introduction: Leprosy reaction is an immunity declining reaction marked with inflammation which may cause permanent disability. Physical exercise may improve body’s immune system. Objective: To prove the effect of moderate-intensity physical exercise on the interleukin-6 level and lymphocyte count in leprosy reaction patient.Methods: The quasi-experimental research with pretest and posttest and a control group design used 30 respondents consisting of 14 interventions and 16 controls. The intervention group was given moderate-intensity physical exercise 60%-79% in the form of static cycle at a frequency of 4 times weekly, 150 minutes per week. Corticosteroid was always administered to the two groups as a standard therapy. The interleukin-6 level was measured using ELISA method and lymphocyte count was measured using hematology analyzer.Result: The Mann-Whitney analysis shows that the mean difference in IL-6 level between pretest and posttest with the intervention group (-7.1429±25.2369) is significantly lower than that of the control group (8.8125±11.2025), p<0.05. On the contrary, the Independent t-test analysis shows that the mean difference in lymphocyte count between pretest and posttest with the intervention group (0.7407±0.41236) is significantly higher than that of the control group (-0.4500±0.42415), p<0.05. Conclusion: Physical exercise at moderate intensity in the form of aerobics using static cycle at a frequency of 4 times weekly, with duration of 150 minutes per week decreases interleukin-6 level and increases lymphocyte count in leprosy reaction patient.

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